Leung AKL, Vyas S, Rood JE, Bhutkar A, Sharp PA, Chang P. Poly(ADP-ribose) regulates stress responses and microRNA activity in the cytoplasm. More recently, he was founding director of the McGovern Institute, a position he held from 2000 to 2004. © 2020 Cold Spring Harbor Laboratory. He has been selected to receive the 2015 Othmer Gold Medal. 617-253-6421 Phone Sharp studies many aspects of gene expression in mammalian cells, including transcription, the roles of non-coding RNAs, and RNA splicing. He details his genealogy, from his great grandparents to his current extended family. After graduating from Falmouth High School, Sharp attended Union College, where he met his wife, Ann Holcombe. PMCID: PMC2587246, room 76-461Aphone (617) 253-6421fax (617) 253-3867email sharppa@mit.edu, phone (617) 253-6458fax (617) 253-3867website, Koch Institute for Integrative Cancer Research Science 322, 1849-1851 (2008). A native of Kentucky, Dr. Sharp earned a B.A. (Media Lab Atrium, 20-Year Sharp Lab Reunion, June 6th, 1994) (Stata Center, 30-Year Sharp Lab Reunion, June, 2004) (McGovern Institute, 40-Year Sharp Lab Reunion, June 14th, 2014) Enter the Sharp Lab Website . Divergent transcription generates thousands of short non-coding RNAs. His landmark achievement was the discovery of RNA splicing in 1977, for which he shared the 1993 Nobel Prize in Physiology or Medicine with Dr. Richard Roberts, who did parallel work at Cold Spring Harbor Laboratory. Annual Reports Contact Giving News History, CSHL Association Directors Corporate Advisory Board Honor Roll of Donors Local Support, Calendar Double Helix Medals Dinner Golf Tournament Women’s Partnership for Science, Donate Now Annual Planned Funds & Endowment, (516) 367-8800 Cell, 169(1), 13-23 (2017). CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. ... Phillip A. Cell 42, 489-99 (2011). The nature of factors or sequences that differentiate the effective elongation of the polymerase in the sense direction as compared to the ineffective elongation in the anti-sense direction remains to be fully identified but appears to involve recognition of nascent RNA by U1 snRNP. He is an elected member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences, the American Philosophical Society, and the Royal Society, UK. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates.
Sharp then discusses his childhood in Falmouth, Kentucky, near Cincinnati, Ohio. The Sharp Laboratory is working to identify physically the target mRNAs for particular miRNAs.

PMCID: PMC2323338, Seila AC, Calabrese JM, Levine SS, Yeo GW, Rahl B, Young RA, Sharp PA. Divergent transcription from active promoters. MicroRNAs organize intrinsic variation into stem cell states. info@cshl.edu Evolution of weak cooperative interactions for biological specificity. He is a member of the National Academy of Sciences, the Institute of Medicine, the American Academy of Arts and Sciences and the American Philosophical Society, and has served on various presidential and national scientific boards. Ventura A, Young AG, Winslow MM, Lintault L, Meissner A, Erkeland SJ, Newman J, Bronson RT, Crowley D, Stone JR, Jaenisch R, Sharp PA, Jacks, T. Targeted deletion reveals essential and overlapping functions of the miR-17~92 family of miRNA clusters. 77 Massachusetts Ave, 68-132 | Cambridge, MA 02139 | 617–253–4701, © 2019 MIT Department of Biology | Credits, Biochemistry, Biophysics, and Structural Biology, Biology Undergraduate Student Association, Interdisciplinary and Joint Degree Programs. Sharp studies many aspects of gene expression in mammalian cells, including transcription, the roles of non-coding RNAs, and RNA splicing. Phillip A. His landmark work in 1977 provided the first indications of “discontinuous genes” in mammalian cells.

Proliferation and tumorigenesis of a murine sarcoma cell line in the absence of DICER1. Spliced segments at the 5' terminus of adenovirus 2 late mRNA. Coactivator condensation at super-enhancers links phase separation and gene control. Gene sequences important for accurate splicing of the nuclear precursors to mRNAs are commonly conserved during evolution. Dr. Sharp is a co-founder of Biogen and Alnylam Pharmaceuticals Inc. Home / Giving / Double Helix Medals Dinner / Past DHMD / 2006 / Phillip Sharp, Ph.D. Dr. Phillip Sharp’s research has centered on the molecular biology of gene expression relevant to cancer and the mechanisms of RNA splicing. The extent of elongation by polymerase in either the sense direction or the antisense direction is controlled by recognition of the nascent RNA by U1 snRNP, a spliceosome component. Institute Professor and Professor of Biology, KI Research Area of Focus:Personalized Medicine, "The Sharp Laboratory focuses on the biology and technology of small RNAs and other types of non-coding RNAs. Cell 132, 875-886 (2008). Divergent transcription from active promoters. These promoters have an RNA polymerase initiated in the sense direction immediately downstream of the transcription start site and a second polymerase initiated in the antisense direction, about 250 base pairs upstream. RNA interference (RNAi) has dramatically expanded the possibilities for genotype/phenotype analysis in cell biology and for therapeutic intervention. Maps & Directions. Moreover, Sharp was instrumental in the establishment of one of the first biotech companies, Genentech, Inc.
RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. For further details about the Sharp Lab, click here. He joined the Center for Cancer Research (now the Koch Institute) in 1974 and served as its director for six years, from 1985 to 1991, before taking over as head of the Department of Biology, a position he held for the next eight years. His landmark achievement was the discovery of RNA splicing in 1977, for which he shared the 1993 Nobel Prize in Physiology or Medicine with Dr. Richard Roberts, who did parallel work at Cold Spring Harbor Laboratory. Cancer Cell 21, 848-55 (2012). Massachusetts Institute of Technology One Bungtown Road, Cold Spring Harbor, NY 11724, Coronavirus Disease 2019 (COVID-19) Advisory, Our website uses cookies to enhance your experience on the site. RNA binding proteins, snRNPs, and regulatory factors control formation of condensates encompassing introns and exons to execute intron removal through formation of a spliceosome. In a study appearing in Nature, researchers from the lab of KI Director and David H. Koch Professor of Biology Tyler Jacks, together with Phillip Sharp’s and Daniel Anderson’s labs, have shown that they can generate liver tumors in adult mice by using CRISPR, a gene-editing tool, to disrupt tumor suppressor genes p53 and pten. He is a member of the advisory board of Polaris Venture Partners; chairman of the scientific advisory board and member of the board of directors, Alnylam Pharmaceuticals; advisor and investor, Longwood and Polaris Venture Funds; member of the boards of directors at Syros Pharmaceuticals and Vir Biotechnology; and member of the scientific advisory board, Dewpoint Therapeutics and Skyhawk Therapeutics. His work has earned him numerous cancer research awards including the Gairdner Foundation International Award, General Motors Research Foundation Alfred P. Sloan, Jr. Prize for Cancer Research, Louisa Gross Horwitz Prize, Albert Lasker Basic Medical Research Award and the National Medal of Science. Nature, 572(7770), 543–548. Dr. Phillip Sharp’s research has centered on the molecular biology of gene expression relevant to cancer and the mechanisms of RNA splicing. Comparable RNA species have also been reported from sequencing data of yeast and Drosophila.

Sharp is Institute Professor (highest academic rank) at the Massachusetts Institute of Technology, member of the Department of Biology and the Koch Institute for Integrative Cancer Research. 500 Main Street, Building 76 By clicking "continue" or by continuing to use our website, you are agreeing to our use of cookies as detailed in our, How one family secured the future of a laboratory, Business Development & Technology Transfer. Dr. Sharp co-founded Biogen, Inc. (now Biogen Idec, Inc.), Alnylam Pharmaceuticals and Magen BioSciences and serves on their Boards of Directors. Surprisingly, the antisense polymerase is controlled by elongation processes very similar to those of sense polymerase. Cambridge MA, 02139-4307 Original Homepage Current Sharpies Alumni/ae Links Current Research Supplementary Data Phil Sharp's CV 30th Reunion Pics P-Day Gallery Core Facilities Reagent Requests Newcomers Guide Site Map Reagent Requests Newcomers Guide Site Map This is the original homepage of the Sharp Lab, designed in 2000 by John Langrill and Margarita Siafaca. 617-253-6403, Clinical Investigators & Research Fellows, Systems & Engineering Approaches to Cancer, Mazumdar-Shaw International Oncology Fellows, 2018: Breakthrough Cancer Nanotechnologies, 2017: Convergence of Science and Engineering in Cancer, 2016: Cancer Prevention and Early Detection, 2014: RNA Biology, Cancer and Therapeutic Implications, November 2020: Nanoparticles and Brain Cancer, April 2019: Machine Learning & Mammography, October 2017: Bridging the Gaps Between Remission and Cure, December 2016: Cancer Nanomedicine with Sangeeta Bhatia, November 2016: Masterclass with Michael Yaffe, November 2015: Masterclass with Robert Weinberg, October 2015: Masterclass with Angela Belcher, October 2014: From Bench to Bedside in Less Than Six Years, May 2014: Bridging the Gap in Pancreatic Cancer, October 2013: Women on the Front Lines in the Fight Against Cancer, October 2013: Cancer Genetics and Precision Cancer Therapy, May 2013: Nanotechnology and Cancer Detection, November 2012: Understanding the Path to Personalized Cancer Care, January 2012: Cancer Stem Cells and Metastasis, 2014 Flash Mob: Immune Cells Fight Cancer, 2012 Flash Mob: Targeted Nanoparticle Therapeutics, Special Advance Screening of CANCER: THE EMPEROR OF ALL MALADIES, Special Symposium: Bridging the Gap in Ovarian Cancer, Preparing ES Cells for Blastocyst Injection, Koch Institute for Integrative Cancer Research. We are investigating the relationship between condensate formation and chromatin structure, transcription and RNA binding factors in control of alternative RNA splicing. The discovery fundamentally changed scientists' understanding of gene structure and earned Dr. Sharp the 1993 Nobel Prize in Physiology or Medicine. Ravi AR, Gurtan AM, Kumar MS, Chin C, Jacks T, Sharp PA. Phillip Sharp worked his way up through the ranks of MIT's administration, eventually becoming head of the biology department and director of the Center for Cancer Research. Dr. Sharp worked as a Senior Scientist at Cold Spring Harbor Laboratory before joining the Massachusetts Institute of Technology (MIT) Center for Cancer Research in 1974, which he directed from 1985 to 1991. A native of Kentucky, Dr. Sharp earned a BA degree from Union College, Barbourville, KY, and a PhD in chemistry from the University of Illinois, Urbana-Champaign in 1969. He subsequently led MIT’s Department of Biology from 1991 to 1999. These divergent nascent RNAs are thought to facilitate the formation of a condensate promoting a burst of transcription. (2019). Dr. Sharp has authored more than 350 scientific papers. https://doi.org/10.1038/s41586-019-1464-0.


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